| Game date | Opposing team | Score | r-h-e | / | r-h-e | Inns | Overall | Big Ten | Pitcher of record | Attend | Time | ||||
| # | Feb 19, 2010 | vs | George Mason | 2-25 | L | 2-8-4 | / | 25-24-1 | 9 | 0-1-0 | 0-0-0 | Jokisch (L 0-1) | 158 | 2:51 | |
| # | Feb 19, 2010 | at | Winthrop | 4-8 | L | 4-9-2 | / | 8-10-0 | 9 | 0-2-0 | 0-0-0 | Muraski (L 0-1) | 476 | 2:41 | |
| # | Feb 20, 2010 | vs | Marist | 2-10 | L | 2-7-2 | / | 10-12-0 | 9 | 0-3-0 | 0-0-0 | Jensen (L 0-1) | 148 | 2:20 | |
| # | Feb 21, 2010 | vs | George Mason | 1-15 | L | 1-5-5 | / | 15-16-1 | 9 | 0-4-0 | 0-0-0 | Jahns (L 0-1) | 243 | 2:43 | |
| Feb 26,2010 | vs | Connecticut | W | 6-5 | 6-12-3 | / | 5-10-5 | (10) | 1-4-0 | 0-0-0 | Jahns (W 1-1) | 357 | 3:02 | ||
| Feb 27, 2010 | vs | Rutgers | W | 7-5 | 7-16-2 | / | 5-10-1 | 9 | 2-4-0 | 0-0-0 | Brooke (W 1-0) | 391 | 2:50 | ||
| Feb 28, 2010 | vs | Seton Hall | 0-3 | L | 0-5-3 | / | 3-6-0 | 9 | 2-5-0 | 0-0-0 | Morton (L 0-1) | 325 | 2:13 | ||
| Mar 05, 2010 | vs | Oklahoma State | 5-7 | L | 5-6-1 | / | 7-11-0 | 9 | 2-6-0 | 0-0-0 | Jokisch (L 0-2) | 0 | 2:18 | ||
| Mar 06, 2010 | vs | Loyola Marymount | W | 3-0 | 3-12-0 | / | 0-3-0 | 9 | 3-6-0 | 0-0-0 | Brooke (W 2-0) | 0 | 2:16 | ||
| Mar 07, 2010 | at | Minnesota | 4-8 | L | 4-12-1 | / | 8-10-1 | 9 | 3-7-0 | 0-0-0 | Morton (L 0-2) | 1052 | 2:34 | ||
| Mar 11, 2010 | at | UNLV | 4-12 | L | 4-10-3 | / | 12-18-1 | 9 | 3-8-0 | 0-0-0 | Muraski (L 0-2) | 309 | 3:00 | ||
| Mar 12, 2010 | at | UNLV | W | 20-6 | 20-13-1 | / | 6-13-2 | 9 | 4-8-0 | 0-0-0 | Brooke (W 2-0) | 0 | 3:28 | ||
| Mar 12, 2010 | at | UNLV | 3-4 | L | 3-8-3 | / | 4-7-1 | 9 | 4-9-0 | 0-0-0 | Jokisch (L 0-3) | 347 | 2:37 | ||
| Mar 13, 2010 | at | UNLV | 8-12 | L | 8-16-3 | / | 12-17-0 | 9 | 4-10-0 | 0-0-0 | Morton (L 0-3) | 317 | 2:53 | ||
| Mar 20, 2010 | vs | UMBC | W | 9-5 | 9-13-3 | / | 5-9-0 | 9 | 5-10-0 | 0-0-0 | Jahns (W 2-1) | 0 | |||
| Mar 20, 2010 | vs | Bucknell | 3-4 | L | 3-8-2 | / | 4-9-1 | (10) | 5-11-0 | 0-0-0 | Gailey (L 0-1) | 125 | 2:41 | ||
| Mar 21, 2010 | vs | Cornell | 3-4 | L | 3-7-2 | / | 4-7-2 | 9 | 5-12-0 | 0-0-0 | Jokisch (L 0-4) | 0 | |||
| Mar 22, 2010 | vs | Cornell | 7-8 | L | 7-16-1 | / | 8-11-0 | 9 | 5-13-0 | 0-0-0 | Snieder (L 0-1) | 0 | |||
| Mar 23, 2010 | vs | Dartmouth | 1-5 | L | 1-7-2 | / | 5-11-1 | 9 | 5-14-0 | 0-0-0 | Jensen (L 0-2) | 0 | |||
| Mar 25, 2010 | at | Stetson | 4-5 | L | 4-13-2 | / | 5-10-1 | 9 | 5-15-0 | 0-0-0 | Jahns (L 2-2) | 691 | 3:10 | ||
| Mar 26, 2010 | at | Stetson | 5-10 | L | 5-14-2 | / | 10-14-1 | 9 | 5-16-0 | 0-0-0 | Brooke (L 3-1) | 798 | 2:50 | ||
| Mar 27, 2010 | at | Stetson | W | 9-7 | 9-7-1 | / | 7-13-4 | 9 | 6-16-0 | 0-0-0 | Jokisch (W 1-4) | 728 | 3:00 | ||
| Mar 28, 2010 | at | Stetson | 5-11 | L | 5-8-2 | / | 11-14-0 | 9 | 6-17-0 | 0-0-0 | Morton (L 0-4) | 714 | 2:40 | ||
| Mar 30, 2010 | at | UIC | 1-6 | L | 1-6-2 | / | 6-9-0 | 9 | 6-18-0 | 0-0-0 | Muraski (L 0-3) | 229 | 2:28 | ||
| * | Apr 02, 2010 | OHIO STATE | 1-11 | L | 1-7-0 | / | 11-17-0 | 9 | 6-19-0 | 0-1-0 | Brooke (L 3-2) | 370 | 2:25 | ||
| * | Apr 03, 2010 | OHIO STATE | W | 8-2 | 8-14-0 | / | 2-8-3 | 9 | 7-19-0 | 1-1-0 | Jokisch (W 2-4) | 240 | 2:20 | ||
| * | Apr 04, 2010 | OHIO STATE | 6-11 | L | 6-14-4 | / | 11-13-2 | 9 | 7-20-0 | 1-2-0 | Muraski (L 0-4) | 300 | 3:05 | ||
| * | Apr 09, 2010 | at | Penn State | W | 11-5 | 11-19-3 | / | 5-10-2 | 9 | 8-20-0 | 2-2-0 | Jensen (W 1-2) | 643 | 2:30 | |
| * | Apr 10, 2010 | at | Penn State | W | 3-2 | 3-12-3 | / | 2-6-2 | (11) | 9-20-0 | 3-2-0 | Morton (W 1-4) | 1324 | 2:27 | |
| * | Apr 11, 2010 | at | Penn State | 5-6 | L | 5-6-4 | / | 6-10-1 | 9 | 9-21-0 | 3-3-0 | Muraski (L 0-5) | 1238 | 2:24 | |
| Apr 14, 2010 | vs | Northern Illinois | W | 6-3 | 6-14-0 | / | 3-7-0 | 9 | 10-21-0 | 3-3-0 | Havey, J. (W 1-0) | 178 | 2:27 | ||
| * | Apr 16, 2010 | MINNESOTA | 7-8 | L | 7-17-1 | / | 8-14-2 | 9 | 10-22-0 | 3-4-0 | Brooke (L 3-3) | 224 | 3:03 | ||
| * | Apr 17, 2010 | MINNESOTA | W | 6-5 | 6-10-0 | / | 5-10-1 | 9 | 11-22-0 | 4-4-0 | Jokisch (W 3-4) | 324 | 2:19 | ||
| * | Apr 18, 2010 | MINNESOTA | W | 8-3 | 8-19-1 | / | 3-9-2 | 9 | 12-22-0 | 5-4-0 | Morton (W 2-4) | 324 | 3:02 | ||
| Apr 21, 2010 | ILLINOIS STATE | W | 3-1 | 3-7-2 | / | 1-3-0 | 9 | 13-22-0 | 5-4-0 | Farrell (W 1-0) | 223 | 2:21 | |||
| * | Apr 24, 2010 | at | Purdue-1 | 1-2 | L | 1-8-1 | / | 2-7-2 | 9 | 13-23-0 | 5-5-0 | Jokisch (L 3-5) | - | 1:53 | |
| * | Apr 24, 2010 | at | Purdue-2 | W | 7-5 | 7-12-3 | / | 5-8-2 | 9 | 14-23-0 | 6-5-0 | Brooke (W 4-3) | 329 | 2:15 | |
| * | Apr 25, 2010 | at | Purdue | W | 6-3 | 6-10-1 | / | 3-6-4 | 9 | 15-23-0 | 7-5-0 | Snieder (W 1-1) | 123 | 3:25 | |
| Apr 28, 2010 | at | Milwaukee-1 | 0-9 | L | 0-3-1 | / | 9-14-0 | 7 | 15-24-0 | 7-5-0 | Farrell (L 1-1) | - | 1:44 | ||
| Apr 28, 2010 | at | Milwaukee-2 | W | 4-1 | 4-10-1 | / | 1-1-1 | 7 | 16-24-0 | 7-5-0 | Havey, J. (W 2-0) | 594 | 1:51 | ||
| * | Apr 30, 2010 | at | Illinois | W | 11-4 | 11-15-4 | / | 4-8-3 | 9 | 17-24-0 | 8-5-0 | Brooke (W 5-3) | 2805 | 2:11 | |
| * | May 01, 2010 | at | Illinois | 3-4 | L | 3-9-0 | / | 4-6-0 | 9 | 17-25-0 | 8-6-0 | Snieder (L 1-2) | 701 | 1:58 | |
| * | May 02, 2010 | at | Illinois | W | 7-5 | 7-10-0 | / | 5-5-0 | 9 | 18-25-0 | 9-6-0 | Morton (W 3-4) | 672 | 2:44 | |
| May 04, 2010 | vs | Valparaiso | W | 10-8 | 10-12-2 | / | 8-15-3 | 9 | 19-25-0 | 9-6-0 | Gailey (W 1-1) | 121 | 2:32 | ||
| May 05, 2010 | UNIV. OF CHICAGO | W | 14-5 | 14-15-1 | / | 5-13-2 | 9 | 20-25-0 | 9-6-0 | Williams (W 1-0) | 118 | 2:44 | |||
| * | May 07, 2010 | INDIANA | 9-11 | L | 9-10-4 | / | 11-15-1 | 9 | 20-26-0 | 9-7-0 | Havey, J. (L 2-1) | 233 | 2:37 | ||
| * | May 08, 2010 | INDIANA | W | 11-4 | 11-15-0 | / | 4-8-5 | 9 | 21-26-0 | 10-7-0 | Jokisch (W 4-5) | 278 | 2:26 | ||
| * | May 09, 2010 | INDIANA | 0-1 | L | 0-4-2 | / | 1-10-0 | 9 | 21-27-0 | 10-8-0 | Brooke (L 5-4) | 306 | 2:16 | ||
| * | May 14, 2010 | at | Michigan | 3-4 | L | 3-9-3 | / | 4-10-0 | 9 | 21-28-0 | 10-9-0 | Jokisch (L 4-6) | 1384 | 2:30 | |
| * | May 15, 2010 | at | Michigan | W | 10-8 | 10-18-1 | / | 8-9-2 | 9 | 22-28-0 | 11-9-0 | Jahns (W 3-2) | 1727 | 3:24 | |
| * | May 16, 2010 | at | Michigan | 14-15 | L | 14-16-2 | / | 15-18-2 | (10) | 22-29-0 | 11-10-0 | Morton (L 3-5) | 1780 | 3:31 | |
| * | May 20, 2010 | MICHIGAN STATE | W | 2-1 | 2-7-1 | / | 1-8-1 | 9 | 23-29-0 | 12-10-0 | Jokisch (W 5-6) | 292 | 1:39 | ||
| * | May 21, 2010 | MICHIGAN STATE | 1-2 | L | 1-4-0 | / | 2-9-0 | 9 | 23-30-0 | 12-11-0 | Snieder (L 1-3) | 340 | 1:49 | ||
| * | May 22, 2010 | MICHIGAN STATE | W | 8-6 | 8-13-3 | / | 6-11-1 | 9 | 24-30-0 | 13-11-0 | Snieder (W 2-3) | 565 | 2:20 | ||
| % | May 26, 2010 | vs | Indiana | 0-5 | L | 0-8-1 | / | 5-14-3 | 9 | 24-31-0 | 13-11-0 | Jokisch (L 5-7) | 369 | 2:22 | |
| % | May 27, 2010 | vs | Purdue | 1-11 | L | 1-10-3 | / | 11-15-0 | 9 | 24-32-0 | 13-11-0 | Brooke (L 5-5) | 366 | 2:28 |
|
* = Conference game
% - Big Ten Tournament; Columbus, Ohio () extra inning game |
